A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

Brioni R Moore; John M Benjamin; Roselyn Tobe; Maria Ome-Kaius; Gumul Yadi; Bernadine Kasian; Charles Kong; Leanne J Robinson; Moses Laman; Ivo Mueller; Stephen Rogerson; Timothy ME Davis

Journal article

A Randomized Open-Label Evaluation of the Antimalarial Prophylactic Efficacy of Azithromycin-Piperaquine versus Sulfadoxine-Pyrimethamine in Pregnant Papua New Guinean Women

Brioni R Moore, John M Benjamin, Roselyn Tobe, Maria Ome-Kaius, Gumul Yadi, Bernadine Kasian, Charles Kong, Leanne J Robinson, Moses Laman, Ivo Mueller, Stephen Rogerson, Timothy ME Davis

Antimicrobial Agents and Chemotherapy | American Society for Microbiology | Published : 2019

DOI: 10.1128/AAC.00302-19

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Abstract

Emerging malaria parasite sulfadoxine-pyrimethamine (SP) resistance has prompted assessment of alternatives for intermittent preventive treatment in pregnancy (IPTp). The objective was to evaluate the tolerability and prophylactic efficacy of azithromycin (AZ) plus piperaquine (PQ) in pregnant women in Papua New Guinea. The study was an open-label, randomized, parallel-group trial. A total of 122 women (median gestation, 26 weeks [range, 14 to 32 weeks]) were randomized 1:1 to three daily doses of 1 g AZ plus 960 mg PQ tetraphosphate or single-dose SP (4,500 mg sulfadoxine plus 225 mg pyrimethamine), based on computer-generated block randomization. Tolerability was assessed to day 7, and eff..

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University of Melbourne Researchers

Ivo Mueller Author

Stephen Rogerson Author

Related Projects (1)

Malaria in Pregnancy: Project Major Activity 7

Grants

Awarded by Malaria in Pregnancy Consortium from Bill and Melinda Gates Foundation

Awarded by National Health and Medical Research Council (NHMRC) Early Career Fellowship

Awarded by NHMRC Early Career Fellowship

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Practitioner Fellowship

Funding Acknowledgements

This study was funded by the Malaria in Pregnancy Consortium, which was funded through a grant from the Bill and Melinda Gates Foundation (grant 46099) to the Liverpool School of Tropical Medicine. B.R.M. was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (grant 1036951), L.J.R. by an NHMRC Early Career Fellowship (grant 1016443), I.M. by an NHMRC Senior Research Fellowship (grant 1043345), and T.M.E.D. by an NHMRC Practitioner Fellowship (grant 572761).